Sedative · Hypnotic · Anticonvulsant · Muscle relaxant · Mammary stimulant

Phemerazole

Also called 3-Methyl-5-phenyl-1H-pyrazole, 5-methyl-3-phenyl-1H-pyrazole, Femerazol

Original Wikipedia articleen.wikipedia.org/wiki/Phemerazole revision used (24 October 2026)

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Overview

Phemerazole, also known as femerazol or 5-phenyl-3-methylpyrazole, is a sedative drug and arylpyrazole derivative. It produces sedative, hypnotic, hypolocomotive, antiaggressive, anticonvulsant, muscle relaxant, and hypothermic effects in animals. In addition to its central nervous system effects, the drug has been found to potentiate the effects of diethylstilbestrol on the mammary glands in animals, including producing ductal and alveolar hyperplasia, stromal hyperemia, and lactogenesis. Its effects in this regard were said to resemble those of the sedative prolactin releasers chlorpromazine and reserpine. The exact mechanisms of action of phemerazole in terms of its various effects do not appear to be known. Phemerazole was first described in the scientific literature by 1960. Various active analogues and derivatives of phemerazole are known.[1–7] WP

Drug class

Sedative Hypnotic Anticonvulsant Muscle relaxant Mammary stimulant WP

From the Wikipedia article's infobox.

Chemistry

Formula: C10H10N2 PC
CAS number: 3347-62-4 PC
Molar mass (g/mol): 158.20 PC
IUPAC name (computed by PubChem): 5-methyl-3-phenyl-1H-pyrazole PC
SMILES: CC1=CC(=NN1)C2=CC=CC=C2 PC
InChIKey: QHRSESMSOJZMCO-UHFFFAOYSA-N PC
PubChem CID: 18774
IUPAC name: 5-methyl-3-phenyl-1H-pyrazole WP

Mixing

For best safety practice, don't mix this drug with other stimulants.

Why: vasoconstriction, heart rate and blood pressure. PsychonautWiki says:

“... may be dangerous to combine with other stimulants ... as they can increase one's heart rate and blood pressure to dangerous levels.” (PsychonautWiki, dangerous interactions table, "Stimulants" row, revision 148925)
“Vasoconstriction can be described as a narrowing of the veins and blood vessels which results from a contraction of their muscular wall.” (PsychonautWiki, Vasoconstriction, revision 170337)
“... it can also occur under the influence of traditional stimulants such as methamphetamine, caffeine, and MDMA.” (PsychonautWiki, Vasoconstriction, revision 170337)
“Increased blood pressure is most commonly induced under the influence of heavy dosages of vasoconstricting compounds, such as traditional stimulants and stimulating psychedelics.” (PsychonautWiki, Increased blood pressure, revision 152273)

Quotes from PsychonautWiki, CC BY-SA 4.0.

Harm reduction information

No harm reduction data is on file for this compound yet. That means no dose, timing or combination data from PsychonautWiki or TripSit. Please don't guess a dose from similar compounds. If you have taken it and feel unwell, contact emergency services or a poison control center.

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User reports

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Listings

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Pop culture

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Sources

Journal / agency Orth RE. Biologically active pyrazoles. Journal of Pharmaceutical Sciences. April 1968. doi:10.1002/jps.2600570401 · PMID 4385101
Other Stanford Research Institute, Psychopharmacology Service Center (U.S.). Psychopharmacology Handbook: Animal Research in Psychopharmacology. 1960
Other Jablonski S. Russian Drug Index. 1967
Journal / agency Pershin GN, Novitskaya NA, Grushina AA. Adjuvant effect of 5-phenyl-3-methylpyrazole (phemerazole) on the action of diethylstilstrol on the mammary glands of rabbits. Biulleten' Eksperimental'noi Biologii I Meditsiny. October 1961. doi:10.1007/BF00788451 · PMID 14038299
Journal / agency Pershin GN, Novitskaia NA, Grushina AA. Potentiation of the effect of diethylstilbestrol on the mammary gland in rabbits under the influence of 3-methyl-5-phenylpyrazole (phemerazole). Biulleten' Eksperimental'noi Biologii I Meditsiny. May 1961. PMID 13734605
Journal / agency Pershin GN, Novitskaia NA. Sedative and hypothermic properties of 3-methyl-5-phenylpyrazole (Phemerazole). Farmakologiia i Toksikologiia. 1960. PMID 13734606
Journal / agency Novitskaia NA, Pershin GN. Effect of 3-methyl-5-phenylpyrazole (phemerazole) on the action of substances stimulating the central nervous system. Farmakologiia i Toksikologiia. 1960. PMID 13729785

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.