Pericine
Also called subincanadine E
One of the alkaloids in akuamma (Picralima nitida) seeds. There are no human studies of it on its own.
Overview
A 1982 paper reported pericine as a new CNS-active indole alkaloid, found in Picralima nitida cell suspension culture by opiate receptor binding studies. [1]
“Pericine is one of a number of indole alkaloids found in the tree Picralima nitida, commonly known as akuamma.” [2]
How it acts
“As with some other alkaloids from this plant such as akuammine, pericine has been shown to bind to mu opioid receptors in vitro, and has an IC50 of 0.6 μmol, within the range of a weak analgesic.” [2]
Risks
“It may also have convulsant effects.” [2]
On harm reduction sites
PsychonautWiki lists pericine in the structure table on its “Substituted tryptamines” page. [3]
Dosage
References
- Journal / agency Arens H, Borbe HO, Ulbrich B, Stöckigt J. Detection of pericine, a new CNS-active indole alkaloid from Picralima nitida cell suspension culture by opiate receptor binding studies. Planta Medica. 1982. doi:10.1055/s-2007-971216 · PMID 6298847 No abstract online; only the title is used here.
- Wikipedia (fallback) Wikipedia contributors. Pericine. Wikipedia. revision 1268790056, read 2026-10-31. https://en.wikipedia.org/w/index.php?oldid=1268790056 CC BY-SA 4.0. Quoted word for word. Used only because no journal abstract or harm reduction site covers these points.
- Harm reduction site PsychonautWiki contributors. Substituted tryptamines. PsychonautWiki. revision 169883, read 2026-10-31. https://psychonautwiki.org/w/index.php?oldid=169883 CC BY-SA 4.0. Lists pericine in its structure table only.
Read 31 October 2026. Very little is published on pericine. The 1982 paper has no abstract online, so the binding figure comes from Wikipedia, which cites that paper; the convulsant line is Wikipedia’s, citing Roberts and Wink, Alkaloids (Springer, 1998).