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Typical antipsychotic

Periciazine

Also called Pericyazine, Propericiazine, Piperocyanomazine

Original Wikipedia articleen.wikipedia.org/wiki/Periciazine revision used (24 October 2026)

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Part of the metabolic pathway of Periciazine. See the timeline on the metabolic highway.

Overview

Periciazine (INN), also known as pericyazine (BAN) or propericiazine, is a drug that belongs to the phenothiazine class of typical antipsychotics.[1] WP

Periciazine is not approved for sale in the United States. It is commonly sold in Canada, Italy and Russia under the tradename Neuleptil and in United Kingdom and Australia under the tradename Neulactil.[2] WP

Drug class

Typical antipsychotic WP

From the Wikipedia article's infobox.

Uses, dosage and effects

Medical uses

The primary uses of periciazine include in the short-term treatment of severe anxiety or tension and in the maintenance treatment of psychotic disorders such as schizophrenia. There is insufficient evidence to determine whether periciazine is more or less effective than other antipsychotics. Dopamine receptor subtype analysis has not been performed for pericyazine, but the drug appears to induce greater noradrenergic than dopaminergic blockade (Nishikawa 1989). Compared to chlorpromazine, pericyazine reportedly has more potent antiemetic, antiserotonin, and anticholinergic activity. A 2014 systematic review compared periciazine with typical antipsychotics for schizophrenia:[3][4] WP⚠ A table follows this text in the source and is not copied here. Open the source to see it.

Periciazine has also been studied in the treatment of opioid dependence.[5] WP

Risks and side effects

Adverse effects

Periciazine is a rather sedating and anticholinergic antipsychotic, and despite being classed with the typical antipsychotics, its risk of extrapyramidal side effects is comparatively low. It has a relatively high risk of causing hyperprolactinaemia and a moderate risk of causing weight gain and orthostatic hypotension.[6] WP

Chemistry

Formula
C21H23N3OS PC
CAS number
2622-26-6 PC
Molar mass (g/mol)
365.5 PC
IUPAC name (computed by PubChem)
10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile PC
SMILES
C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N PC
InChIKey
LUALIOATIOESLM-UHFFFAOYSA-N PC
PubChem CID
4747

Harm reduction information

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Sources

  1. Journal / agency Stępnicki P, Kondej M, Kaczor AA. Current Concepts and Treatments of Schizophrenia. Molecules. August 2018. doi:10.3390/molecules23082087 · PMID 30127324 · PMC6222385
  2. Other Martindale: The Complete Drug Reference. 23 September 2011
  3. Other NEULACTIL PRODUCT INFORMATION. 13 September 2011
  4. Journal / agency Matar HE, Almerie MQ, Makhoul S, Xia J, Humphreys P. Pericyazine for schizophrenia. The Cochrane Database of Systematic Reviews. May 2014. doi:10.1002/14651858.CD007479.pub2 · PMID 24825770 · PMC11023599
  5. Journal / agency Sivolap I, Savchenkov VA. The use of neuroleptics in treating opiate dependence. Zhurnal Nevrologii I Psikhiatrii imeni S.S. Korsakova. 1999. PMID 10441864
  6. Other Approximate relative frequency (not intensity) of common adverse effects of antipsychotics (Table 8.21) [NB1]. February 2013

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.