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Compound

Pefloxacin

Also called 1589-RB, Pefocin, Pefbid

Original Wikipedia articleen.wikipedia.org/wiki/Pefloxacin revision used (24 October 2026)

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Part of the metabolic pathway of Pefloxacin. See the timeline on the metabolic highway.

Overview

Pefloxacin is a quinolone antibiotic used to treat bacterial infections. Pefloxacin has not been approved for use in the United States. WP

Risks and side effects

Adverse effects

Tendinitis and rupture, usually of the Achilles tendon, are class-effects of the fluoroquinolones, most frequently reported with pefloxacin. The estimated risk of tendon damage during pefloxacin therapy has been estimated by the French authorities in 2000 to be 1 case per 23,130 treatment days as compared to ciprofloxacin where it has been estimated to be 1 case per 779,600.[1][2] WP

History

History

Pefloxacin was developed in 1979 and approved in France for human use in 1985.[3] WP

Chemistry

Formula
C17H20FN3O3 PC
CAS number
70458-92-3 PC
Molar mass (g/mol)
333.36 PC
IUPAC name (computed by PubChem)
1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid PC
SMILES
CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCN(CC3)C)F)C(=O)O PC
InChIKey
FHFYDNQZQSQIAI-UHFFFAOYSA-N PC
PubChem CID
51081
IUPAC name
1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid WP

Harm reduction information

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Sources

  1. Journal / agency Khaliq Y, Zhanel GG. Musculoskeletal injury associated with fluoroquinolone antibiotics. Clin Plast Surg. October 2005. doi:10.1016/j.cps.2005.05.004 · PMID 16139623
  2. Journal / agency Casparian JM, Luchi M, Moffat RE, Hinthorn D. Quinolones and tendon ruptures. South. Med. J. May 2000. doi:10.1097/00007611-200093050-00008 · PMID 10832946
  3. Other http://www.bailii.org/ew/cases/EWHC/Patents/2008/2413.html. 15 October 2008

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.