Parafluorofentanyl
Also called PFF, 4-Fluorofentanyl, Fentanyl 4-Fluoro, p-Fluorofentanyl, IDS-NF-003
Dosage
Insufflated
TripSit dose text
TripSit's factsheet also states its doses as text.
Insufflated Light: 10-25ug Common: 25-40ug Strong: 40-65ug+ TS
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Duration
TripSit factsheet
Mixing
For best safety practice, don't mix this drug with other depressants.
Why: respiratory depression. PsychonautWiki says:
- “Respiratory depression (also known as hypoventilation) can be described as a reduced urge to breathe that can be fatal depending on its intensity.” (PsychonautWiki, Respiratory depression, revision 150612)
- “... otherwise safe dosages of these compounds can become fatal when combined with even small amounts of other classes of depressant. For example, benzodiazepines combined with opioids are an extremely common cause of fatal respiratory depression. It is therefore strongly discouraged to combine these depressants at any dosage range.” (PsychonautWiki, Respiratory depression, revision 150612)
- “The most common cause of substance-related deaths is the combination of depressants (such as opiates, benzodiazepines, or alcohol) with other depressants.” (PsychonautWiki, Responsible drug use, revision 168206)
- “This combination potentiates the muscle relaxation, amnesia, sedation, and respiratory depression caused by one another. At higher doses, it can lead to a sudden, unexpected loss of consciousness along with a dangerous amount of depressed respiration.” (PsychonautWiki, dangerous interactions table, "Depressants" row, revision 156847)
Quotes from PsychonautWiki, CC BY-SA 4.0.
Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.
Backed by medical journals
TripSit combination chart
TripSit rates each pairing. Only pairings with a number carry a citation from TripSit. See the whole chart; TripSit's own notes are on combo.tripsit.me.
Risks and toxicity
Testing
Effects
Overview
Rare, little known and extremely potent analogue of Fentanyl developed by Janssen Pharmaceutica in the 1960s. Use with extreme caution and never mix with other depressants. TS
Parafluorofentanyl (4-fluorofentanyl, para-fluorofentanyl, pFF) is an opioid analgesic analogue of fentanyl developed by Janssen Pharmaceuticals in the 1960s. WP
Parafluorofentanyl was sold briefly on the US black market in the early 1980s, before the introduction of the Federal Analog Act which for the first time attempted to control entire families of drugs based on their structural similarity rather than scheduling each drug individually as they appeared. Parafluorofentanyl is made by the same synthetic route as fentanyl, but by substituting para-fluoroaniline for aniline in the synthesis.[1]
Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea, and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed thousands of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.[3] WP
In 2020, the Drug Enforcement Agency warned about the increasing prevalence of parafluorofentanyl in Arizona.[4]
History
Legal status
Pharmacology
Chemistry
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References
- Journal / agency Henderson GL. Designer drugs: past history and future prospects. Journal of Forensic Sciences. March 1988. doi:10.1520/JFS11976J · PMID 3286815
- Journal / agency Ulens C, Van Boven M, Daenens P, Tytgat J. Interaction of p-fluorofentanyl on cloned human opioid receptors and exploration of the role of Trp-318 and His-319 in μ-opioid receptor selectivity. The Journal of Pharmacology and Experimental Therapeutics. September 2000. doi:10.1016/S0022-3565(24)39167-0 · PMID 10945855
- Journal / agency Mounteney J, Giraudon I, Denissov G, Griffiths P. Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe. The International Journal on Drug Policy. July 2015. doi:10.1016/j.drugpo.2015.04.003 · PMID 25976511
- Other DEA warns of newly encountered fentanyl-like drug in Arizona. December 28, 2020
- Other DEA in Arizona warns of 'extremely dangerous' form of fentanyl. December 29, 2020
Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), TripSit factsheets, PubChem (public domain). Each value links to the exact revision it came from.