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Compound

Para-Methoxyphenylpiperazine

Also called MeOPP, 4-methoxyphenylpiperazine, pMeOPP, Paraperazine

Original Wikipedia articleen.wikipedia.org/wiki/Para-Methoxyphenylpiperazine revision used (24 October 2026)

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Part of the metabolic pathway of Para-Methoxyphenylpiperazine. See the timeline on the metabolic highway.

Enzymes that break it down: CYP2D6. Wikipedia’s drug infobox says: “The human liver P450 CYP2D6 converts para-methoxyphenylpiperazine by demethylation to para-hydroxyphenylpiperazine.” (revision 1339954691).

Overview

para-Methoxyphenylpiperazine (pMeOPP), also known as 4-methoxyphenylpiperazine (4-MeOPP), is a substituted piperazine derivative with stimulant effects which has been sold as an ingredient in "Party pills", initially in New Zealand and subsequently in other countries around the world.[1] WP

Pharmacology

Pharmacology

pMeOPP is anecdotally said to induce significantly less anxiety than similar piperazines, and is usually taken at doses between 120–200 mg. However it is often mixed with stimulant piperazine derivatives such as benzylpiperazine (BZP) for a combined effect. WP

pMeOPP has been found in vitro to inhibit the reuptake and induce the release of the monoamine neurotransmitters. This is a mechanism of action shared with drugs of abuse such as amphetamines, and pMeOPP produces somewhat similar effects although it is much less potent and is thought to have relatively insignificant abuse potential. Piperazine derivatives such as trifluoromethylphenylpiperazine (TFMPP) have also been shown to exert a major part of their mechanism of action as nonselective serotonin receptor agonists, and pMeOPP has also been demonstrated to act in this way.[2][3] WP

Legal status

Finland

Scheduled in the "government decree on psychoactive substances banned from the consumer market".[4] WP

New zealand

Based on the recommendation of the EACD, the New Zealand government has passed legislation which placed BZP, along with a number of other piperazine derivatives into Class C of the New Zealand Misuse of Drugs Act 1975. A ban was intended to come into effect in New Zealand on December 18, 2007, but the law change did not go through until the following year, and the sale of BZP and the other listed piperazines became illegal in New Zealand as of 1 April 2008. An amnesty for possession and usage of these drugs remained until October 2008, at which point they became completely illegal.[5] WP

United states

pMeOPP is not scheduled at the federal level in the United States.[6] WP

Florida

"Methoxyphenylpiperazine" is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess in Florida.[7] WP

Chemistry

Formula
C11H16N2O PC
CAS number
38212-30-5 PC
Molar mass (g/mol)
192.26 PC
IUPAC name (computed by PubChem)
1-(4-methoxyphenyl)piperazine PC
SMILES
COC1=CC=C(C=C1)N2CCNCC2 PC
InChIKey
MRDGZSKYFPGAKP-UHFFFAOYSA-N PC
PubChem CID
269722
IUPAC name
1-(4-methoxyphenyl)piperazine WP

Harm reduction information

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Sources

  1. Journal / agency Elliott S. Current awareness of piperazines: pharmacology and toxicology. Drug Test Anal. 2011. doi:10.1002/dta.307 · PMID 21744514
  2. Journal / agency Nagai F, Nonaka R, Satoh Hisashi Kamimura K. The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain. European Journal of Pharmacology. March 2007. doi:10.1016/j.ejphar.2006.11.075 · PMID 17223101
  3. Journal / agency Maurer HH, Kraemer T, Springer D, Staack RF. Chemistry, pharmacology, toxicology, and hepatic metabolism of designer drugs of the amphetamine (ecstasy), piperazine, and pyrrolidinophenone types: a synopsis. Therapeutic Drug Monitoring. April 2004. doi:10.1097/00007691-200404000-00007 · PMID 15228152
  4. Other Valtioneuvoston asetus kuluttajamarkkinoilta kielletyistä psykoaktiivisista aineista
  5. Other Misuse of Drugs (Classification of BZP) Amendment Bill 2008
  6. Other 21 CFR — SCHEDULES OF CONTROLLED SUBSTANCES §1308.11 Schedule I
  7. Other Florida Statutes - Chapter 893 - DRUG ABUSE PREVENTION AND CONTROL

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.