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Compound

Para-Fluorophenylpiperazine

Also called pFPP, Flipiperazine, 4-Fluoro-phenylpiperazine, 4-FPP

Original Wikipedia articleen.wikipedia.org/wiki/Para-Fluorophenylpiperazine revision used (24 October 2026)

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Part of the metabolic pathway of Para-Fluorophenylpiperazine. See the timeline on the metabolic highway.

Overview

para-Fluorophenylpiperazine (pFPP, 4-FPP, 4-Fluorophenylpiperazine; Fluoperazine, Flipiperazine) is a piperazine derivative with mildly psychedelic and euphoriant effects. It has been sold as an ingredient in legal recreational drugs known as "Party pills", initially in New Zealand and subsequently in other countries around the world.[1][2][3] WP

pFPP has been found in vitro to act mainly as a 5-HT1A receptor agonist, with some additional affinity for the 5-HT2A and 5-HT2C receptors. It has also been shown to inhibit the reuptake of serotonin and norepinephrine, and to possibly induce their release. WP

pFPP was originally discovered as a metabolite of the hypnotic 5-HT2A and α₁-adrenergic receptor antagonist niaprazine in 1982, but was rediscovered in 2003 as a potential recreational drug, and sold as an ingredient in "Party pills" in New Zealand, under brand names such as "The Big Grin", "Mashed", and "Extreme Beans". Subsequently it has continued to be used as an ingredient in black market "ecstasy" pills around the world.[4][5] WP

pFPP has little stimulant effects, with its subjective effects derived mainly from its action as a 5-HT1A receptor agonist. pFPP is active at doses between 20 and 150 mg, but higher doses cause a range of side-effects such as migraine headaches, muscle aches, anxiety, nausea, and vomiting. Metabolic studies have shown pFPP to be an inhibitor of various Cytochrome P450 enzymes in the liver which may contribute to its side-effect profile.[6][7] WP

Based on the recommendation of the EACD, the New Zealand government has passed legislation which placed BZP, along with a number of other piperazine derivatives, into Class C of the New Zealand Misuse of Drugs Act 1975. A ban was intended to come into effect in New Zealand on December 18, 2007, but the law change did not go through until the following year, and the sale of BZP and the other listed piperazines became illegal in New Zealand as of 1 April 2008. An amnesty for possession and usage of these drugs remained until October 2008, at which point they became completely illegal. This drug has been detected in a drug-facilitated sexual assault case in the United States of America.[8] WP⚠ Wikipedia itself has flagged this text: citation needed.

Chemistry

Formula
C10H13FN2 PC
CAS number
2252-63-3 PC
Molar mass (g/mol)
180.22 PC
IUPAC name (computed by PubChem)
1-(4-fluorophenyl)piperazine PC
SMILES
C1CN(CCN1)C2=CC=C(C=C2)F PC
InChIKey
AVJKDKWRVSSJPK-UHFFFAOYSA-N PC
PubChem CID
75260

Harm reduction information

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Sources

  1. Harm reduction site Erowid Experience Vaults: Piperazines - pFPP - Refreshing Enhancement - 62575
  2. Harm reduction site Erowid Experience Vaults: Piperazines - pFPP - A Little Flip'd Out - 56641
  3. Other King LA. Forensic Chemistry of Substance Misuse. A Guide to Drug Control. Royal Society of Chemistry. (2009) pp 100–102 ISBN 978-0-85404-178-7
  4. Other Keane PE, Strolin Benedetti M, Dow J. The effect of niaprazine on the turnover of 5-hydroxytryptamine in the rat brain. Neuropharmacology. 1982 Feb;21(2):163-9
  5. Other DEA Microgram Bulletin August 2009
  6. Other Scherman D, Hamon M, Gozlan H, Henry JP, Lesage A, Masson M, Rumigny JF. Molecular pharmacology of niaprazine. Progress in Neuro-psychopharmacology and Biological Psychiatry. 1988;12(6):989-1001
  7. Journal / agency Antia U, Tingle MD, Russell BR. Metabolic interactions with piperazine-based 'party pill' drugs. The Journal of Pharmacy and Pharmacology. July 2009. doi:10.1211/jpp.61.07.0006 · PMID 19589229
  8. Other Misuse of Drugs (Classification of BZP) Amendment Bill 2008

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.