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Compound

Oxaflozane

Original Wikipedia articleen.wikipedia.org/wiki/Oxaflozane revision used (24 October 2026)

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Part of the metabolic pathway of Oxaflozane. See the timeline on the metabolic highway.

Overview

Oxaflozane (INN; brand name Conflictan) is an antidepressant and anxiolytic drug that was introduced by Solvay in France in 1982 for the treatment of depression but has since been discontinued. It is a prodrug of flumexadol (N-dealkyloxaflozane; 2-(3-trifluoromethylphenyl)morpholine; CERM-1841 or 1841-CERM), which is reported to act as an agonist of the serotonin 5-HT1A (pKᵢ = 7.1) and 5-HT2C (pKᵢ = 7.5) receptors and, to a much lesser extent, of the 5-HT2A (pKᵢ = 6.0) receptor. In addition to its serotonergic properties, oxaflozane may also produce anticholinergic side effects at high doses, namely in overdose.[1–6] WP

Chemistry

Formula
C14H18F3NO PC
CAS number
26629-87-8 PC
Molar mass (g/mol)
273.29 PC
IUPAC name (computed by PubChem)
4-propan-2-yl-2-[3-(trifluoromethyl)phenyl]morpholine PC
SMILES
CC(C)N1CCOC(C1)C2=CC(=CC=C2)C(F)(F)F PC
InChIKey
FVYUQFQCEOZYHZ-UHFFFAOYSA-N PC
PubChem CID
432824

Harm reduction information

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Sources

  1. Other Elks J. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014
  2. Other Swiss Pharmaceutical Society. Index Nominum 2000: International Drug Directory (Book with CD-ROM). 2000
  3. Other Sittig M. Pharmaceutical Manufacturing Encyclopedia. 1988
  4. Other Bégué JP, Bonnet-Delpon D. Bioorganic and Medicinal Chemistry of Fluorine. 2 June 2008
  5. Journal / agency Leysen DC. Selective 5-HT2C agonists as potential antidepressants. IDrugs. February 1999. PMID 16160946
  6. Journal / agency Dutertre JP, Barbier P, Suc AL, Jonville AP, Autret E. Oxaflozane overdose in a child. Journal of Toxicology. Clinical Toxicology. 1992. doi:10.3109/15563659208994452 · PMID 1542141

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.