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Substance

Olanzapine/fluoxetine

Original Wikipedia articleen.wikipedia.org/wiki/Olanzapine/fluoxetine revision used (24 October 2026)

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Overview

Olanzapine/fluoxetine (trade name Symbyax, created by Eli Lilly and Company) is a fixed-dose combination medication containing olanzapine (Zyprexa), an atypical antipsychotic, and fluoxetine (Prozac), a selective serotonin reuptake inhibitor (SSRI). Olanzapine/fluoxetine is primarily used to treat the depressive episodes of bipolar I disorder as well as treatment-resistant depression.[1][2][3] WP

Uses, dosage and effects

Medical uses

Olanzapine/fluoxetine was approved by the U.S. Food and Drug Administration (FDA) to treat the depressive episodes of bipolar I disorder in 2003. In 2009, it was granted approval for the treatment of treatment-resistant depression.[2][4] WP

Olanzapine/fluoxetine, or other antidepressant/antipsychotic combinations, are sometimes prescribed off-label for anxiety disorders, eating disorders, obsessive–compulsive disorder (OCD), and posttraumatic stress disorder (PTSD).[5–8] WP

Risks and side effects

Side effects

Possible side effects of olanzapine/fluoxetine include all those of the two component drugs: olanzapine (side effects) and fluoxetine (side effects). Common side effects include suicidal thoughts, increased appetite, weight gain, drowsiness, fatigue, dry mouth, swelling, tremor, blurred vision, and difficulty concentrating.[2] WP

Olanzapine/fluoxetine could produce a severe allergic reaction and should not be used if the patient has previously experienced an allergic reaction to either fluoxetine or olanzapine.[9] WP

Olanzapine is correlated with an increase in blood sugar. Patients with diabetes, or those at risk for developing it, require careful monitoring.[9] WP

In rare cases, olanzapine/fluoxetine may cause neuroleptic malignant syndrome.[2] WP

Like other SSRIs, olanzapine/fluoxetine carries a boxed warning stating that it could increase the risk of suicidal thoughts and behaviors in patients aged 24 and under. The warning also states that olanzapine/fluoxetine may increase the risk of death in elderly patients with dementia-related psychosis.[2] WP

Chemistry

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Harm reduction information

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Sources

  1. Other Tratamento medicamentoso dos transtornos bipolares - Transtornos psiquiátricos
  2. Journal / agency Symbyax- olanzapine and fluoxetine hydrochloride capsule. 21 April 2020
  3. Journal / agency Benazzi F, Berk M, Frye MA, Wang W, Barraco A, Tohen M. Olanzapine/fluoxetine combination for the treatment of mixed depression in bipolar I disorder: a post hoc analysis. The Journal of Clinical Psychiatry. October 2009. doi:10.4088/JCP.08m04772gre · PMID 19906346
  4. Other Grohol, J. FDA Approves Symbyax for Treatment Resistant Depression
  5. Journal / agency McIntyre R, Katzman M. The role of atypical antipsychotics in bipolar depression and anxiety disorders. Bipolar Disorders. 2003. doi:10.1111/j.1399-2406.2003.00061.x · PMID 14700010
  6. Journal / agency Pederson KJ, Roerig JL, Mitchell JE. Towards the pharmacotherapy of eating disorders. Expert Opinion on Pharmacotherapy. October 2003. doi:10.1517/14656566.4.10.1659 · PMID 14521477
  7. Journal / agency Koran LM, Ringold AL, Elliott MA. Olanzapine augmentation for treatment-resistant obsessive-compulsive disorder. The Journal of Clinical Psychiatry. July 2000. doi:10.4088/JCP.v61n0709 · PMID 10937610
  8. Journal / agency Stein MB, Kline NA, Matloff JL. Adjunctive olanzapine for SSRI-resistant combat-related PTSD: a double-blind, placebo-controlled study. The American Journal of Psychiatry. October 2002. doi:10.1176/appi.ajp.159.10.1777 · PMID 12359687
  9. Other Symbyax

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