Opioid

Noroxymorphone

Also called 14-Hydroxydihydronormorphinone

Original Wikipedia articleen.wikipedia.org/wiki/Noroxymorphone revision used (24 October 2026)

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Part of the metabolic pathway of Oxycodone and Oxymorphone. See the timeline on the metabolic highway.

Overview

Noroxymorphone is an opioid which is both a metabolite of oxymorphone and oxycodone and is manufactured specifically as an intermediate in the production of opioid antagonists such as naltrexone and others. It is a potent agonist of the μ-opioid receptor, but is poorly able to cross the blood–brain barrier into the central nervous system, and for this reason, has only minimal analgesic activity.[1][2][3] WP

In the United States, noroxymorphone is controlled as a Schedule II Narcotic controlled substance with an ACSCN of 9637. In 2014, the DEA set annual aggregate manufacturing quotas of 17,500 kg for conversion and 1,262.5 kg for sale.[4] WP

Drug class

Opioid WP

From the Wikipedia article's infobox.

Chemistry

Formula: C16H17NO4 PC
CAS number: 33522-95-1 PC
Molar mass (g/mol): 287.31 PC
IUPAC name (computed by PubChem): (4R,4aS,7aR,12bS)-4a,9-dihydroxy-1,2,3,4,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one PC
SMILES: C1C[C@]2([C@H]3CC4=C5[C@@]2(CCN3)[C@H](C1=O)OC5=C(C=C4)O)O PC
InChIKey: HLMSIZPQBSYUNL-IPOQPSJVSA-N PC
PubChem CID: 5497189
IUPAC name: 7,8-Dihydro-14-hydroxynormorphinone WP

Mixing

For best safety practice, don't mix this drug with other depressants.

Why: respiratory depression. PsychonautWiki says:

“Respiratory depression (also known as hypoventilation) can be described as a reduced urge to breathe that can be fatal depending on its intensity.” (PsychonautWiki, Respiratory depression, revision 150612)
“... otherwise safe dosages of these compounds can become fatal when combined with even small amounts of other classes of depressant. For example, benzodiazepines combined with opioids are an extremely common cause of fatal respiratory depression. It is therefore strongly discouraged to combine these depressants at any dosage range.” (PsychonautWiki, Respiratory depression, revision 150612)
“The most common cause of substance-related deaths is the combination of depressants (such as opiates, benzodiazepines, or alcohol) with other depressants.” (PsychonautWiki, Responsible drug use, revision 168206)
“This combination potentiates the muscle relaxation, amnesia, sedation, and respiratory depression caused by one another. At higher doses, it can lead to a sudden, unexpected loss of consciousness along with a dangerous amount of depressed respiration.” (PsychonautWiki, dangerous interactions table, "Depressants" row, revision 156847)

Quotes from PsychonautWiki, CC BY-SA 4.0.

Harm reduction information

No harm reduction data is on file for this compound yet. That means no dose, timing or combination data from PsychonautWiki or TripSit. Please don't guess a dose from similar compounds. If you have taken it and feel unwell, contact emergency services or a poison control center.

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User reports

Erowid erowid.org

Listings

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Bluelight bluelight.org

Listings

Awaiting sourceTrip report threads and this substance's discussion forum.

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Listings

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Pop culture

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Sources

Journal / agency Lemberg KK, Siiskonen AO, Kontinen VK, Yli-Kauhaluoma JT, Kalso EA. Pharmacological characterization of noroxymorphone as a new opioid for spinal analgesia. Anesthesia and Analgesia. February 2008. doi:10.1213/ane.0b013e3181605a15 · PMID 18227301
Other Preedy VR. Neuropathology of Drug Addictions and Substance Misuse Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions. 25 April 2016
Other Smith H, Passik S. Pain and Chemical Dependency. 25 April 2008
Other Drug Enforcement Administration. Final Adjusted Aggregate Production Quotas for Schedule I and II Controlled Substances and Assessment of Annual Needs for the List I Chemicals Ephedrine, Pseudoephedrine, and Phenylpropanolamine for 2014. August 25, 2014

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.