intoxicant.wiki2catechol4school
Layout
Other

MGM-15

Also called dihydro-7-hydroxymitragynine, DH-7OH-MG, DHM

Related pages: 7-OH · Mitragynine · Mitragynine pseudoindoxyl · Kratom

Overview

“In September 2025, a new synthetic (i.e. not naturally occurring) but also semi-synthetic (i.e. derived from MG) kratom alkaloid, dihydro-7-hydroxy mitragynine (DH-7OH-MG, aka MGM-15) ( Fig. 1 ), was detected in materials being offered for sale, further adding to the diversity of products on the market.” [1]

“DH-7OH-MG is reported to be about 30 times more potent than MG” [1]

“DH-7OH-MG has been sold as a “research chemical” online and, more recently, under the guise of “proprietary blend” or “nanotech” labeling, following a trajectory similar to other kratom alkaloid products.” [1]

“Marketing has also switched to use of the acronym “DHM,” shifting from “MGM-15,” the name associated with its first literature source” [1]

Gour et al. describe MGM-15 as a synthetic derivative of 7-hydroxymitragynine in which stereospecific saturation of the imine N(1)–C(2) double bond increases opioid receptor affinity and activity. They report it is sold in the US for human consumption as a “research chemical” in tablet form, has not been studied in humans, and has no FDA approval. [2]

Risks and toxicity

“Products containing 7OH-MG, MP, and synthetically derived dihydro-7-hydroxy mitragynine (DH-7OH-MG, aka MGM-15) exhibit greater potencies and activities at the µ-opioid receptor compared to MG and are now highly implicated in intoxications and deaths.” [1]

In receptor binding tests, MGM-15 showed greater binding affinity than 7-hydroxymitragynine at the human mu (hMOR) and delta (hDOR) opioid receptors. The authors say this indicates the potential for higher opioid effects and risks. [2]

A case series describes a 38-year-old with escalating use of 7-OH and MGM-15 who needed 32 mg/8 mg of buprenorphine/naloxone to treat severe opioid withdrawal symptoms after stopping MGM-15 tablets. The authors write that these kratom derivatives can produce opioid-like dependence. [3]

“Since July, Utah and Tennessee officials have reported overdoses, deaths, and laboratory findings involving tablets labeled as cat’s claw ( Uncaria tomentosa ), an herbal supplement without known opioid activity.” [4]

Dosage

Awaiting sourceNo dose range from PsychonautWiki, TripSit or a journal yet.

What tested products contained

These are lab measurements of what was inside products, not doses. No harm reduction site or journal we checked gives a dose range for MGM-15.

Commercial tablets labelled “MGM” contained an average of 10.9 ± 0.2 mg (10.7 to 11.2 mg) of MGM-15 each, with no naturally occurring kratom alkaloids or illicit substances detected. [2]

“None of the 46 products declared kratom alkaloids or their derivatives, yet all contained at least one component. Mitragynine was quantified in 41 products (89%; 95% CI, 76% to 96%), 7-OH in 35 (76%; 95% CI, 61% to 87%), MGM-15 in 24 (52%; 95% CI, 37% to 67%), and MPI in 22 (48%; 95% CI, 33% to 63%).” [4]

“Eight products carrying claims such as “NO KRATOM and No 7-OH” or “NO 7-OH” contained mitragynine and 7-OH.” [4]

Mixing

Awaiting sourceNo interaction data from a harm reduction site or journal yet.

Testing

“The same properties that allow derivation (e.g. adding acid) make routine testing techniques difficult, with interconversion between alkaloids possible upon addition of heat, acid, or base (e.g. conversion of DH-7OH-MG to MG, MG to 7OH-MG, and 7OH-MG to MP)” [1]

“MG, MP, and DH-7OH-MG were relatively stable in blood, whereas 7OH-MG decreased quickly and by 89% over 112 days with a concurrent increase in MP.” [1]

“In a second subset ( n = 17), the mean ± SD DH-7OH-MG (MGM-15) concentration was 324 ± 669 ng/ml (median: 170 ng/ml, range: 50–2900 ng/ml).” [1]

“Testing for kratom alkaloids is currently extremely limited and/or subject to potential inaccuracies due to interconversion, leaving adverse events and fatalities under-investigated.” [1]

Chemistry

“DH-7OH-MG has previously been mentioned alongside 10-fluoro dihydro-7-hydroxy mitragynine (aka MGM-16) in early research, demonstrating the realm of possibilities for new synthetic alkaloids” [1]

References

  1. Journal / agency Eccarius LK, Walton SE, Papsun DM, Logan BK, Krotulski AJ. Quantification of kratom alkaloids mitragynine, 7-hydroxy mitragynine, mitragynine pseudoindoxyl, and dihydro-7-hydroxy mitragynine in forensic casework and medicolegal death investigations. Journal of Analytical Toxicology. 2026. doi:10.1093/jat/bkag090 · PMID 42879701 Open access, CC BY. Quoted word for word.
  2. Journal / agency Gour A, Mukhopadhyay S, Henderson A, Awad A, Seabra MA, Pullman M, León F, Cutler SJ, McCurdy CR, Sharma A. From Kratom to Semi-Synthetic Opioids: The Rise and Risks of MGM-15. Drug Testing and Analysis. 2025. doi:10.1002/dta.3952 · PMID 40936282 Not open access (Unpaywall checked), so findings are cited from the abstract, not quoted.
  3. Journal / agency Gormley MA, Wampler WR, Darby T, Mann D, McElmurray K, Brophy B, Elkes J, Beltran GW, Litwin AH, Fabiano S. Community Paramedics Addressing the Evolving Opioid Crisis: A Case Series Addressing the Kratom Derivatives 7-Hydroxymitragynine and MGM-15. Prehospital Emergency Care. 2026. doi:10.1080/10903127.2026.2753000 · PMID 42911834 Not open access (Unpaywall checked), so findings are cited from the abstract, not quoted.
  4. Preprint Avula B, Katragunta K, Tatapudi KK, Bae J, Chittiboyina AG, Khan IA. Undeclared Kratom Alkaloids and Tianeptine in Products Labeled as Cat’s Claw. medRxiv (preprint, not peer reviewed). 2026. doi:10.64898/2026.10.16.26365420 CC0. Quoted word for word. A preprint has not been peer reviewed.

Read 30 October 2026. PsychonautWiki, TripSit and Wikipedia had no MGM-15 article when checked, and PubChem had no entry under “MGM-15” or “dihydro-7-hydroxymitragynine”.