O-PCE

Dosage

When sources disagree, both rows are shown as published. Nothing is averaged or merged.

Oral

Insufflated

TripSit dose text

TripSit's factsheet also states its doses as text.

Oral Light: 3-6mg Common: 6-11mg Strong: 10-20mg. Insufflated Light: 3-5mg Common: 5-10mg Strong: 10-20mg. TS

Duration

TripSit factsheet

Onset

Insufflated: 15-45 minutes · Oral: 25-75 minutes TS

Duration

Insufflated: 2-5 hours · Oral: 3-6 hours TS

Aftereffects

2-48 hours TS

Mixing

Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.

Backed by medical journals

Other documented combinations

• Alcohol - Even low doses of alcohol can cause severe interactions. Nausea, vomiting, amnesia, and other negative effects are extremely likely when mixed. PW⚠ PsychonautWiki lists this combination without a danger rating.

PsychonautWiki also lists dangerous combinations shared across a whole group (dissociatives) in a table this page does not copy. Read that list on PsychonautWiki.

Risks and toxicity

The toxicity and long-term health effects of recreational O-PCE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because O-PCE has very little history of human usage. Anecdotal evidence from people who have tried O-PCE within the community suggests that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). PW

O-PCE shares a close structural relationship to deschloroketamine (O-PCM) and ketamine (2-Cl-O-PCM), which has been speculated to have immuno-modulative properties. It is not known whether O-PCE also has these properties due to the lack of sufficient scientific research. However, the possibility should be kept in mind because prolonged use could potentially pose a serious threat to one's health and immune system.[9] PW

It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance to ensure the accurate administration of the intended dose. PW

Tolerance and addiction potential

As with other NMDA receptor antagonists, the chronic use of O-PCE can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. PW

Tolerance to many of the effects of O-PCE develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). O-PCE presents cross-tolerance with all dissociatives, meaning that after the consumption of O-PCE all dissociatives will have a reduced effect. PW

Urinary tract effects

In terms of its long-term health effects when used repeatedly and excessively for extended periods of time, O-PCE seems to exhibit similar bladder and urinary tract problems to those found within ketamine, although to what extent is unclear. This is likely because O-PCE is significantly more potent than ketamine, meaning that less of the drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as: PW

• Urinary frequency - Urinary frequency is the need to empty the bladder every few minutes. PW
• Urinary urgency - This can be described as a sudden, compelling need to urinate. PW
• Urinary pressure - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination. PW
• Pelvic and bladder pain - Pain can develop suddenly and severely, particularly as the bladder fills with urine. PW
• Hematuria - Hematuria is visible blood in the urine. PW
• Incontinence - This is the leakage of urine. PW

However, anecdotal evidence suggests that these symptoms can be largely avoided by refraining from using O-PCE on a regular basis (e.g. weekly at the bare minimum) and carefully monitoring and limiting one's intake of the substance. PW

TripSit factsheet

Avoid

CNS depressants. TS

Testing

User reports