PCE

Dosage

When sources disagree, both rows are shown as published. Nothing is averaged or merged.

Oral

Smoked

Insufflated

TripSit dose text

TripSit's factsheet also states its doses as text.

Insufflated Light: 1-3mg Common: 3-7mg Strong: 7-15mg+ TS

Duration

TripSit factsheet

Duration

2-5 hours TS

Aftereffects

1-4 hours TS

Onset

Insufflated 5-15 minutes. TS

Mixing

Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.

Backed by medical journals

Other documented combinations

• Psychedelics - This combination is not advised because PCE has been reported to cause extreme psychological disturbances such as psychosis and mania at a significantly higher rate than other dissociatives. PW⚠ PsychonautWiki lists this combination without a danger rating.

PsychonautWiki also lists dangerous combinations shared across a whole group (dissociatives) in a table this page does not copy. Read that list on PsychonautWiki.

Risks and toxicity

The long-term use of PCE may lead to schizophrenia-like psychotic episodes, severe lasting memory loss, disorganized thinking, depression, weight loss, liver abnormalities and rhabdomyolysis (skeletal muscle breakdown).[7] PW

Some studies have found that, like other NMDA receptor antagonists, PCE can cause brain damage called Olney's lesions in rats. Studies conducted on rats showed that high doses of the NMDA receptor antagonist dizocilpine caused reversible vacuoles to form in certain regions of the rats' brains. All studies of Olney's lesions have only been performed on non-human animals and may not apply to humans.[8][9] PW

PCE has also been shown to cause schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate levels in the rat brain, which are detectable both in living rats and upon necropsy examination of brain tissue. It also induces symptoms in humans that mimic schizophrenia.[10][11] PW

It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance to ensure the administration of the intended dose. PW

Tolerance and addiction potential

The chronic use of PCE can be considered highly addictive with a high potential for adverse side effects such as psychosis. In comparison to other dissociatives, PCE has been reported to be more addictive than MXE, diphenidine, ephenidine, and ketamine. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. There have been multiple reports across the internet of people becoming seriously addicted daily users of this substance so serious precautions and considerations should be taken before trying this substance. PW

Tolerance to many of the effects of PCE develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). PCE presents cross-tolerance with all dissociatives, meaning that after the consumption of PCE, all dissociatives will have a reduced effect. PW

Psychosis

PCE is reported to cause psychosis and mania at a significantly higher rate than other dissociatives such as ketamine, diphenidine, or MXE. Multiple scientific papers describe states of psychosis, mania, and/or delirium occurring after moderate to large doses of the drug were ingested. In one initial human trial, it was reported that one-sixth of the patients who had received anesthetic doses became psychotic. In some cases, it took up to a week or more to resolve. Similar results (although less severe) were reported during trials using subanesthetic doses of PCE for pain relief.[12] PW

It is strongly recommended that one use extreme caution and harm reduction practices when using this drug. PW

• Users should avoid taking the drug multiple days in a row or becoming addicted to it as this increases the risk of severe adverse effects. PW
• The recommended dosage range should not be exceeded as high doses can trigger adverse effects. PW
• Users should start with extremely low doses and work their way up as slowly as possible. Volumetric liquid dosing should preferably be used due to the drug's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg. PW
• Compulsive redosing before one has fully sobered up is not recommended and can result in too high of a dose. PW

Due to the risk of psychosis, it is not recommended to combine this drug with other substances, especially stimulants, psychedelics, or other dissociatives like MXE. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. PW

Urinary tract effects

In terms of its long-term health effects when used repeatedly and excessively for extended periods of time, PCE seems to exhibit similar extreme bladder and urinary tract problems to those found with other arylcyclohexylamines like ketamine or PCP. PW

• Urinary frequency - Urinary frequency is the need to empty the bladder every few minutes. PW
• Urinary urgency - This can be described as a sudden, compelling need to urinate. PW
• Urinary pressure - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination. PW
• Pelvic and bladder pain - Pain can develop suddenly and severely, particularly as the bladder fills with urine. PW
• Hematuria - Hematuria is visible blood in the urine. PW
• Incontinence - This is the leakage of urine. PW

A large body of anecdotal evidence suggests that these symptoms can be minimized by not using PCE on a regular basis (daily or weekly at the bare minimum) and carefully monitoring and limiting one's usage of the substance, although general usage of this substance is still discouraged due to its observed toxic properties. PW

Testing

User reports