Psychedelic · Stimulant

TMA-2

Also called 2,4,5-Trimethoxyamphetamine

Original Wikipedia articleen.wikipedia.org/wiki/Trimethoxyamphetamine revision used (24 October 2026)

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Common dose · Oral20–40 mg PW

Onset20–120 minutes PW

Total8–12 hours PW

After-effects4–24 hours PW

Dosage

Light

Common

Strong

Heavy

0510204060mg

Oral bands as drawn from PsychonautWiki's ranges below. The table is the source of truth.

When sources disagree, both rows are shown as published. Nothing is averaged or merged.

Oral

Source	Threshold	Light	Common	Strong	Heavy
PsychonautWiki	5 mg PW	10–20 mg PW	20–40 mg PW	40–60 mg PW	60 mg+ PW
TripSit	5–10 mg TS	10–20 mg TS	20–40 mg TS	40–60 mg+ TS	–

TripSit dose text

TripSit's factsheet also states its doses as text.

Threshold: 5-10mg Light: 10-20mg Common: 20-40mg Strong: 40-60mg+ TS

What dose are you on? (self-reported, unverified)

Read this first. These numbers come from anonymous visitors typing in a box. Nobody checks them. People misjudge, mistype, troll, or take untested products of unknown strength. They are not a dose guide and never override the sourced table above. They exist only so the sourced ranges can be compared with what people say they take. If you are deciding what to take, use the sourced table, start low, and read the risks section.

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Duration

Onset

Come-up

Peak

Offset

0h1h2h3h4h5h6h7h8h9h10h11h

Oral, drawn at the midpoint of each PsychonautWiki range.

Route · source	Onset	Come-up	Peak	Offset	Total	After-effects
Oral · PsychonautWiki	20–120 minutes PW	1.5–3 hours PW	4–6 hours PW	2–4 hours PW	8–12 hours PW	4–24 hours PW

TripSit factsheet

Onset: 20-120 minutes TS
Duration: 6-12 hours TS

Mixing

For best safety practice, don't mix this drug with other stimulants.

Why: vasoconstriction, heart rate and blood pressure. PsychonautWiki says:

“... may be dangerous to combine with other stimulants ... as they can increase one's heart rate and blood pressure to dangerous levels.” (PsychonautWiki, dangerous interactions table, "Stimulants" row, revision 148925)
“Vasoconstriction can be described as a narrowing of the veins and blood vessels which results from a contraction of their muscular wall.” (PsychonautWiki, Vasoconstriction, revision 170337)
“... it can also occur under the influence of traditional stimulants such as methamphetamine, caffeine, and MDMA.” (PsychonautWiki, Vasoconstriction, revision 170337)
“Increased blood pressure is most commonly induced under the influence of heavy dosages of vasoconstricting compounds, such as traditional stimulants and stimulating psychedelics.” (PsychonautWiki, Increased blood pressure, revision 152273)

Quotes from PsychonautWiki, CC BY-SA 4.0.

Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.

Backed by medical journals

Awaiting sourcePeer-reviewed reports on acute combinations, from PubMed and the journals the harm reduction sites cite.

Risks and toxicity

Toxicity studies in rats have been showed TMA-2 doses of 80 mg/kg induced frequent clonic convulsions. A dose of 120 mg/kg was associated with fatal toxic effects. It was estimated that the LD50 of mice to be 180mg/kg.[1] PW

The toxicity and long-term health effects of recreational TMA-2 use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because TMA-2 has very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried TMA-2 suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. PW

Tolerance and addiction potential

TMA-2 is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating. PW

Tolerance to the effects of TMA-2 are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). TMA-2 presents cross-tolerance with all psychedelics, meaning that after the consumption of TMA-2 all psychedelics will have a reduced effect. PW

Testing

Awaiting sourceReagent reactions and test kit guidance from a harm reduction testing service.

Effects

Euphoria empathy insight brightened colour Closed/Open eye visuals enhanced tactile sensation mental/physical stimulation decreased appetite pupil dilation restlessness change in perception ego softening sweating/chills muscle tension confusion insomnia TS

Shulgin notes

These figures come from the Shulgins' own small trials, published decades ago. They are history, not a dosing guide: they were never checked the way a harm reduction dose table is, and batches, purity and people differ.

Book: PiHKAL (1991), entry #158
Dose listed: 20–40 mg orally WP
Duration listed: 8–12 hours WP

Read entry #158 in Erowid's online library

From PiHKAL and TiHKAL by Alexander and Ann Shulgin, as tabulated in Wikipedia's articles on the books (CC BY-SA 4.0). The books' text belongs to the Shulgins, so only the listed figures and a link are given here. Synthesis details are never shown on this site.

Overview

2,4,5-Trimethoxyamphetamine (abbreviated TMA-2) is a synthetic psychedelic amphetamine known to produce a unique spectrum of hallucinogenic and stimulant effects that differ substantially from other psychoactive phenethylamines. TMA-2 along with TMA-6 and others are members of the trimethoxylated family of phenethylamines. Members in this family been observed to produce a complex mixture of hallucinogenic, stimulant, psychedelic and entactogenic effects that qualitatively separates it from other psychedelic phenethylamine compounds like members of the 2C-x or DOx series. PW

Trimethoxyamphetamine-2, a psychedelic amphetamine and stimulant first synthesised by Alexander Shulgin. An uncommon compound of similar activity to other psychedelic amphetamines. Short history of human use. TS

History

Awaiting sourceHistory and culture from Wikipedia or PsychonautWiki, with their citations.

Legal status

In November 2003, the European Council decided that TMA-2 shall be subjected by the Member States to control measures and criminal penalties within three months.[2] PW
Austria: TMA-2 is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich). PW⚠ PsychonautWiki itself has flagged this text: citation needed.
Germany: TMA-2 is controlled under Anlage I BtMG (Narcotics Act, Schedule I) as of October 10, 1999. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.[3][4][5] PW
Switzerland: TMA-2 is a controlled substance specifically named under Verzeichnis D.[6] PW
Turkey: TMA-2 is a classed as drug and is illegal to possess, produce, supply, or import.[7][8] PW
United Kingdom: TMA-2 is a controlled Class A drug under the Misuse of Drugs Act 1977 and is covered by the generic definition (TMA-2 is a positional isomer of the UN controlled drug TMA). PW⚠ PsychonautWiki itself has flagged this text: citation needed.

Pharmacology

Awaiting sourcePharmacology from Wikipedia and the journal papers it cites.

Chemistry

Awaiting sourceFormula, structure and identifiers from PubChem.

User reports

Erowid erowid.org

Listings

Erowid Experience Vault listing

Link as published on TripSit's factsheet.

Bluelight bluelight.org

Listings

Awaiting sourceTrip report threads and this substance's discussion forum.

Reddit reddit.com

Listings

Awaiting sourceTrip report posts and the relevant subreddits.

Pop culture

No references added yet.

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References

Other Report on the risk assessment of TMA-2 in the framework of the joint action on new synthetic drugs. 2004
Other COUNCIL DECISION 2003/847/JHA. November 27, 2003
Other Dreizehnte Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften
Other Anlage I BtMG
Other § 29 BtMG
Other Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien
Other https://resmigazete.gov.tr/eskiler/2014/01/20140125-3.htm
Other https://resmigazete.gov.tr/eskiler/2014/01/20140125-3-1.pdf

Text and values on this page are quoted from PsychonautWiki (CC BY-SA 4.0), Wikipedia (CC BY-SA 4.0), TripSit factsheets. Each value links to the exact revision it came from.