TMA-6
Also called 2,4,6-Trimethoxyamphetamine
Dosage
Oral bands as drawn from PsychonautWiki's ranges below. The table is the source of truth.
When sources disagree, both rows are shown as published. Nothing is averaged or merged.
Oral
| Source | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| PsychonautWiki | 5 mg PW | 10–20 mg PW | 20–35 mg PW | 35–50 mg PW | 50 mg+ PW |
| TripSit | 15–20 mg TS | 20–30 mg TS | 30–40 mg TS | – | 40–50 mg+ TS |
TripSit dose text
TripSit's factsheet also states its doses as text.
Threshold: 15-20mg Light: 20-30mg Common: 30-40mg Heavy: 40-50mg+ TS
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Duration
Oral, drawn at the midpoint of each PsychonautWiki range.
| Route · source | Onset | Come-up | Peak | Offset | Total | After-effects |
|---|---|---|---|---|---|---|
| Oral · PsychonautWiki | 30–90 minutes PW | 1.5–3 hours PW | 5–8 hours PW | 3–5 hours PW | 10–16 hours PW | 6–18 hours PW |
TripSit factsheet
Mixing
For best safety practice, don't mix this drug with other stimulants.
Why: vasoconstriction, heart rate and blood pressure. PsychonautWiki says:
- “... may be dangerous to combine with other stimulants ... as they can increase one's heart rate and blood pressure to dangerous levels.” (PsychonautWiki, dangerous interactions table, "Stimulants" row, revision 148925)
- “Vasoconstriction can be described as a narrowing of the veins and blood vessels which results from a contraction of their muscular wall.” (PsychonautWiki, Vasoconstriction, revision 170337)
- “... it can also occur under the influence of traditional stimulants such as methamphetamine, caffeine, and MDMA.” (PsychonautWiki, Vasoconstriction, revision 170337)
- “Increased blood pressure is most commonly induced under the influence of heavy dosages of vasoconstricting compounds, such as traditional stimulants and stimulating psychedelics.” (PsychonautWiki, Increased blood pressure, revision 152273)
Quotes from PsychonautWiki, CC BY-SA 4.0.
Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.
Backed by medical journals
- Tramadol - Tramadol lowers the seizure threshold and psychedelics may act as triggers for seizures, particularly in those who are predisposed to them.[1] PW⚠ PsychonautWiki itself has flagged this text: citation needed.⚠ PsychonautWiki lists this combination without a danger rating.
Other documented combinations
- Stimulants - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable anxiety, panic, thought loops and paranoia. This interaction may cause elevated risk of psychosis. PW⚠ PsychonautWiki itself has flagged this text: citation needed.⚠ PsychonautWiki lists this combination without a danger rating.
- Lithium - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its glutaminergic and GABAergic effects. PW⚠ PsychonautWiki itself has flagged this text: citation needed.⚠ PsychonautWiki lists this combination without a danger rating.
PsychonautWiki also lists dangerous combinations shared across a whole group (serotonin syndrome) in a table this page does not copy. Read that list on PsychonautWiki.
Risks and toxicity
The toxicity and long-term health effects of recreational TMA-6 use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because TMA-6 has very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried TMA-6 suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. PW
Tolerance and addiction potential
Though largely unstudied TMA-6 is largely considered to be not habit-forming and the desire to use it can actually decrease with consumption. It is most often self-regulating. PW
Tolerance to the effects of TMA-6 are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). TMA-6 presents cross-tolerance with all psychedelics, meaning that after the consumption of TMA-6 all psychedelics and stimulants will have a reduced effect. PW
Testing
Effects
Euphoriaempathyinsightbrightened colourClosed/Open eye visualsenhanced tactile sensationmental/physical stimulationdecreased appetitepupil dilationrestlessnesschange in perceptionego softeningsweating/chillsmuscle tensionconfusioninsomnia TS
Shulgin notes
These figures come from the Shulgins' own small trials, published decades ago. They are history, not a dosing guide: they were never checked the way a harm reduction dose table is, and batches, purity and people differ.
Read entry #162 in Erowid's online library
From PiHKAL and TiHKAL by Alexander and Ann Shulgin, as tabulated in Wikipedia's articles on the books (CC BY-SA 4.0). The books' text belongs to the Shulgins, so only the listed figures and a link are given here. Synthesis details are never shown on this site.
Overview
2,4,6-Trimethoxyamphetamine (also known as TMA-6) is a lesser-known psychedelic substance of the amphetamine class. It has been reported to produce a complex mixture of stimulant, hallucinogenic and entactogenic effects that distinguish it from other psychedelic phenethylamine derivatives like the 2C-x or DOx series. PW
A rarely seen Psychedelic Amphetamine and Mescaline analogue. First synthesised by Alexander Shulgin, who descrived it as "one of the most rewarding and pleasurable of the methoxylated amphetamines." TS
History
Legal status
- Germany: TMA-6 is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.[2]
[3] [4] PW - Switzerland: TMA-6 is not specifically named, although it can be considered an ether analog of an ether analog of PMA, which would make it illegal according to Buchstabe C.[5] PW
- Turkey: TMA-6 is a classed as drug and is illegal to possess, produce, supply, or import.[6]
[7] PW
Pharmacology
Chemistry
User reports
Erowid erowid.org
ListingsErowid Experience Vault listing
Link as published on TripSit's factsheet.
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References
- Journal / agency Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., Abdollahi, M. Dose-independent occurrence of seizure with tramadol. Journal of Medical Toxicology. June 2009. doi:10.1007/BF03161089
- Other Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe
- Other Anlage NpSG
- Other § 4 NpSG
- Other Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien
- Other Başbakanlık Mevzuatı Geliştirme ve Yayın Genel Müdürlüğü
- Other https://resmigazete.gov.tr/eskiler/2014/01/20140125-3-1.pdf
Text and values on this page are quoted from PsychonautWiki (CC BY-SA 4.0), Wikipedia (CC BY-SA 4.0), TripSit factsheets. Each value links to the exact revision it came from.