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Venlafaxine

What the body does with Venlafaxine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

VenlafaxinetakendesvenlafaxinemetaboliteExitKidney (87%; 5% as unchanged drug; 29% a

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    42±15% 1

  2. hoursbreakdown

    Metabolism

    Extensively metabolised by the liver, primarily via CYP2D6 1

  3. hoursmade from it

    Metabolites

    O-desmethylvenlafaxine (ODV), see desvenlafaxine 1

  4. half-lifehalf gone

    Elimination half-life

    5±2 h (parent compound for immediate release preparations), 15±6 h (parent compound for extended-release preparations), 11±2 h (active metabolite) 1

  5. exitleaves the body

    Excretion

    Kidney (87%; 5% as unchanged drug; 29% as desvenlafaxine and 53% as other metabolites) 1

Source

  1. Wikipedia, Venlafaxine, drug infobox (revision 1371433947), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.