intoxicant.wiki2catechol4school
← All metabolic timelinesMetabolic highway

Thalidomide

What the body does with Thalidomide, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

ThalidomidetakenExitUrine, feces and semen

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    90% 1

  2. hoursbreakdown

    Metabolism

    Liver (minimally via CYP2C19-mediated 5-hydroxylation; mostly via non-enzymatic hydrolysis at the four amide sites) 1

  3. half-lifehalf gone

    Elimination half-life

    5–7.5 hours (dose-dependent) 1

  4. exitleaves the body

    Excretion

    Urine, feces and semen 1

Source

  1. Wikipedia, Thalidomide, drug infobox (revision 1376197756), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.