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Temsirolimus

What the body does with Temsirolimus, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

TemsirolimustakenSirolimusmetaboliteExitUrine (4.6%), faeces (78%)

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. hoursbreakdown

    Metabolism

    Liver 1

  2. hoursfrom the article text

    What else it turns into

    “It is a derivative and prodrug of sirolimus.” 2

  3. half-lifehalf gone

    Elimination half-life

    17.3 hours (temsirolimus); 54.6 hours (sirolimus) 1

  4. exitleaves the body

    Excretion

    Urine (4.6%), faeces (78%) 1

Sources

  1. Wikipedia, Temsirolimus, drug infobox (revision 1334750108), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.
  2. Wikipedia, Temsirolimus, article text (revision 1334750108), CC BY-SA 4.0. Sentences quoted as they appear.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.