intoxicant.wiki2catechol4school
← All metabolic timelinesMetabolic highway

Spironolactone

What the body does with Spironolactone, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

Spironolactonetakencanrenonemetabolite7α-Thiospironolactonemetabolite7α-ThiomethylspironolactonemetaboliteExitUrine, bile

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    60–90% 1

  2. hoursbreakdown

    Metabolism

    Liver, others: Deacetylation via CES; S-Oxygenation via FOM; S-Methylation via TMT; Dethioacetylation; Hydroxylation via CYP3A4; Lactone hydrolysis via PON3 1

  3. hoursmade from it

    Metabolites

    7α-TS, 7α-TMS, 6β-OH-7α-TMS, canrenone, others; (All three active) 1

  4. hoursfrom the article text

    What else it turns into

    “Other important metabolites of spironolactone include 7α-thiospironolactone (7α-TS; SC-24813), 6β-hydroxy-7α-thiomethylspironolactone (6β-OH-7α-TMS), and canrenone (SC-9376).” 2 “As an antiandrogen, 7α-TP4 has approximately 8.5% of the affinity of dihydrotestosterone (DHT) for the rat ventral prostate androgen receptor (AR), which is similar to that of spironolactone and its active metabolite 7α-thiomethylspironolactone.” 3

  5. half-lifehalf gone

    Elimination half-life

    Spironolactone: 1.4 hrs; 7α-TMS: 13.8 hours; 6β-OH-7α-TMS: 15.0 hrs; Canrenone: 16.5 hours 1

  6. exitleaves the body

    Excretion

    Urine, bile 1

Sources

  1. Wikipedia, Spironolactone, drug infobox (revision 1369649243), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.
  2. Wikipedia, 7α-Thiomethylspironolactone, article text (revision 1364326892), CC BY-SA 4.0. Sentences quoted as they appear.
  3. Wikipedia, 7α-Thioprogesterone, article text (revision 1359553339), CC BY-SA 4.0. Sentences quoted as they appear.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.