intoxicant.wiki2catechol4school
← All metabolic timelinesMetabolic highway

Sirolimus

What the body does with Sirolimus, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

SirolimustakenExitMostly fecal

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    14% (oral solution), lower with high-fat meals; 18% (tablet), higher with high-fat meals 1

  2. hoursbreakdown

    Metabolism

    Liver 1

  3. half-lifehalf gone

    Elimination half-life

    57–63 hours 1

  4. exitleaves the body

    Excretion

    Mostly fecal 1

Source

  1. Wikipedia, Sirolimus, drug infobox (revision 1378350482), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.