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Sildenafil

What the body does with Sildenafil, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

SildenafiltakenExitFeces (~80%), urine (~13%)

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    20 minutes 1

  2. doseabsorbed

    Bioavailability

    41% (mean) 1

  3. hoursbreakdown

    Metabolism

    Liver: CYP3A4 (major route), CYP2C9 (minor route) 1

  4. hoursmade from it

    Metabolites

    N-desmethylsildenafil (~50% potency for PDE₅) 1

  5. half-lifehalf gone

    Elimination half-life

    3–4 hours 1

  6. exitleaves the body

    Excretion

    Feces (~80%), urine (~13%) 1

Source

  1. Wikipedia, Sildenafil, drug infobox (revision 1376217569), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.