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Sertraline

What the body does with Sertraline, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

SertralinetakenDesmethylsertralinemetabolite

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    ~40–45% 1

  2. hoursbreakdown

    Metabolism

    Liver (primarily N-demethylation mainly by CYP2B6; also metabolism by CYP2C19, others) 1

  3. hoursmade from it

    Metabolites

    Desmethylsertraline; Others (e.g., hydroxylated metabolites, glucuronide conjugates) 1

  4. half-lifehalf gone

    Elimination half-life

    Sertraline: 26 hours (32 hours in females, 22 hours in males; range 13–45 hours); Desmethylsertraline: 62–104 hours 1

Source

  1. Wikipedia, Sertraline, drug infobox (revision 1375702628), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.