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Ramelteon

What the body does with Ramelteon, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

RamelteontakenExitKidney: 84%; Feces: 4%

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    1.8% 1

  2. hoursbreakdown

    Metabolism

    Liver (CYP1A2 major, CYP2C and CYP3A4 minor) 1

  3. hoursmade from it

    Metabolites

    M-II (active metabolite) 1

  4. half-lifehalf gone

    Elimination half-life

    Ramelteon: 1–2.6 hours; M-II: 2–5 hours 1

  5. exitleaves the body

    Excretion

    Kidney: 84%; Feces: 4% 1

Source

  1. Wikipedia, Ramelteon, drug infobox (revision 1362641733), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.