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Psilocybin

Follow one dose of psilocybin from the moment it enters the body until the last of it leaves.

PsilocybinprodrugPsilocinactive, via phosphatasePsilocin-O-glucuronidevia UGTs4-HIAA and othersvia MAO-A, 4–33%Urine2–4% as psilocin

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0.5–0.8 honset

    Dose taken by mouth

    onset 0.5–0.8 hpeak 1–2.2 hlasts 4–6 h

    Effects start on average 0.5–0.8 hours after an oral dose, peak at about 1.0–2.2 hours, and last about 4–6 hours, with a range of 3–12.1

  2. firstgut and liver

    Psilocybin → psilocin

    alkaline phosphatasepsilocin is active

    Phosphatase enzymes, listed as alkaline phosphatase, remove psilocybin's phosphate group to make psilocin, the active compound.1

  3. 2–5 hpsilocin half-life

    Psilocin → glucuronide and 4-HIAA

    UGTsMAO-Ahalf-life 2.1–4.7 h

    Psilocin is joined to glucuronic acid by UGT enzymes and broken down by MAO-A. Estimates of the MAO share range from 4% to 33%.1 Psilocin's half-life is 2.1–4.7 hours, with a range of 1.2–18.6.1

    Mixing: TripSit rates mushrooms with lithium as Dangerous. With MAOIs it rates them Low Risk & Synergy, since MAO-A is one of the enzymes that breaks psilocin down.12
  4. ~1 dayexit

    Out through the kidneys

    mostly psilocin-O-glucuronide2–4% unchanged

    Urine is the main route out. Most is psilocin-O-glucuronide, and 2–4% is unchanged psilocin.1

Sources

  1. Wikipedia, Psilocybin (pharmacokinetics and infobox), CC BY-SA
  2. TripSit combination chart (combos.json, read 2026-10-24)

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.