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Psilocin

What the body does with Psilocin, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

PsilocintakenExitUrine (mainly as psilocin-O-glucuronide,

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    15–40 minutes 1

  2. doseabsorbed

    Bioavailability

    Oral psilocybin: 52.7 ± 20.4% (as psilocin) 1

  3. hoursbreakdown

    Metabolism

    Liver, other tissues: Demethylation and deamination (MAO); Oxidation (ALDH); Glucuronidation (UGTs) 1

  4. hoursmade from it

    Metabolites

    Psilocin-O-glucuronide; 4-Hydroxy-indole-3-acetaldehyde; 4-Hydroxyindole-3-acetic acid (4-HIAA); 4-Hydroxytryptophol 1

  5. half-lifehalf gone

    Elimination half-life

    Oral psilocybin: 2.3–3 hours (as psilocin); IV psilocybin: 1.2 hours (as psilocin) 1

  6. durationeffects

    Duration of action

    3–6 hours 1

  7. exitleaves the body

    Excretion

    Urine (mainly as psilocin-O-glucuronide, 2–4% unchanged) 1

Source

  1. Wikipedia, Psilocin, drug infobox (revision 1368850101), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.