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Phenylephrine

What the body does with Phenylephrine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

PhenylephrinetakenExitUrine: 86% (3–16% unchanged)

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    IV: Very rapid; Oral: 15–20 min; Intranasal: <2 min; Eye drop: <30 min 1

  2. doseabsorbed

    Bioavailability

    Oral: conflicting—38% or 0.003% 1

  3. hoursbreakdown

    Metabolism

    Liver and intestines (via oxidative deamination by MAO-A and MAO-B; sulfation; glucuronidation) 1

  4. hoursmade from it

    Metabolites

    meta-Hydroxymandelic acid; Sulfate conjugates; Glucuronide conjugates 1

  5. half-lifehalf gone

    Elimination half-life

    2–3 hours 1

  6. durationeffects

    Duration of action

    IV: 20 min–5 h; Oral: 2–4 h; Intranasal: 0.5–4 h; Eye drop: 3–7 h 1

  7. exitleaves the body

    Excretion

    Urine: 86% (3–16% unchanged) 1

Source

  1. Wikipedia, Phenylephrine, drug infobox (revision 1378630754), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.