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Palonosetron

What the body does with Palonosetron, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

PalonosetrontakenExitKidney, 80% (of which 49% unchanged); fe

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    97% (oral) 1

  2. hoursbreakdown

    Metabolism

    Liver, 50% (mostly CYP2D6-mediated, CYP3A4 and CYP1A2 also involved) 1

  3. half-lifehalf gone

    Elimination half-life

    Approximately 40–50 hours 1

  4. exitleaves the body

    Excretion

    Kidney, 80% (of which 49% unchanged); fecal (5 to 8%) 1

Source

  1. Wikipedia, Palonosetron, drug infobox (revision 1333743869), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.