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Nicotine

What the body does with Nicotine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

NicotinetakenCotininemetaboliteExitRenal, urine pH-dependent; 10–20% (gum),

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    Inhalation: 80–90%; Intranasal: 60–80%; Transdermal: 68–100% 1

  2. hoursbreakdown

    Metabolism

    Primarily hepatic: CYP2A6, CYP2B6, FMO3, others 1

  3. hoursmade from it

    Metabolites

    Cotinine, Nornicotine, others 1

  4. half-lifehalf gone

    Elimination half-life

    1–2 hours; 16–19 hours cotinine (range is 10–27 hours) 1

  5. exitleaves the body

    Excretion

    Renal, urine pH-dependent; 10–20% (gum), 30% (inhaled); 10–30% (intranasal) 1

Source

  1. Wikipedia, Nicotine, drug infobox (revision 1378750548), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.