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Neostigmine

What the body does with Neostigmine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

NeostigminetakenExitUnchanged drug (up to 70%) and alcoholic

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    Within 10-20 min (injection), with 4 hrs (by mouth) 1

  2. doseabsorbed

    Bioavailability

    Unclear, probably less than 5% 1

  3. hoursbreakdown

    Metabolism

    Slow hydrolysis by acetylcholinesterase and also by plasma esterases 1

  4. half-lifehalf gone

    Elimination half-life

    50–90 minutes 1

  5. durationeffects

    Duration of action

    up to 4 hrs 1

  6. exitleaves the body

    Excretion

    Unchanged drug (up to 70%) and alcoholic metabolite (30%) are excreted in the urine 1

Source

  1. Wikipedia, Neostigmine, drug infobox (revision 1378436331), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.