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Morphine

What the body does with Morphine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

MorphinetakenExitKidney 90%, bile duct 10%

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    IV: 5 minutes; IM: 15 minutes; PO: 20 minutes 1

  2. doseabsorbed

    Bioavailability

    IV/IM: 100%; Intranasal: 10%; PO: 20–40%; Rectal: 36–71% 1

  3. hoursbreakdown

    Metabolism

    Liver: UGT2B7 1

  4. hoursmade from it

    Metabolites

    Morphine-3-glucuronide (90%); Morphine-6-glucuronide (10%) 1

  5. half-lifehalf gone

    Elimination half-life

    2–3 hours 1

  6. durationeffects

    Duration of action

    3–7 hours 1

  7. exitleaves the body

    Excretion

    Kidney 90%, bile duct 10% 1

Source

  1. Wikipedia, Morphine, drug infobox (revision 1374517907), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.