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Modafinil

What the body does with Modafinil, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

ModafiniltakenExitUrine: 80% (≤10% as modafinil, 35 % as m

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    2 hour (peak) 1

  2. doseabsorbed

    Bioavailability

    40 % (based on urinary excretion) 1

  3. hoursbreakdown

    Metabolism

    Liver (amide hydrolysis, S-oxidation, aromatic ring hydroxylation, glucuronide conjugation; CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5 involved) 1

  4. hoursmade from it

    Metabolites

    Modafinil acid (35 %); Modafinil sulfone 1

  5. half-lifehalf gone

    Elimination half-life

    Modafinil: 12 hour; Armodafinil: 10 hour; Esmodafinil: 3 hour 1

  6. durationeffects

    Duration of action

    11.5 hour 1

  7. exitleaves the body

    Excretion

    Urine: 80% (≤10% as modafinil, 35 % as modafinil acid); Feces: 1.0% 1

Source

  1. Wikipedia, Modafinil, drug infobox (revision 1375967552), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.