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Methadone

What the body does with Methadone, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

MethadonetakenExitUrine, faeces

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    Rapid 1

  2. doseabsorbed

    Bioavailability

    Rectal: 76% SC: 79%; Oral: 41–99% IV/IM: 100% 1

  3. hoursbreakdown

    Metabolism

    Liver (CYP3A4, CYP2B6 and CYP2D6-mediated) 1

  4. hoursmade from it

    Metabolites

    EDDP; EDMP; para-Hydroxymethadone 1

  5. half-lifehalf gone

    Elimination half-life

    15–55 hours 1

  6. durationeffects

    Duration of action

    Single dose: 4–8 h; Prolonged use: Withdrawal prevention: 1–2 days; Pain relief: 8–12 hours 1

  7. exitleaves the body

    Excretion

    Urine, faeces 1

Source

  1. Wikipedia, Methadone, drug infobox (revision 1376375440), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.