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Loxapine

What the body does with Loxapine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

LoxapinetakenAmoxapinemetaboliteExitMajority are excreted within 24 hours, m

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. hoursbreakdown

    Metabolism

    Extensive Liver; active metabolites include amoxapine and 8-hydroxyloxapine. Inhibits P-gp and is a substrate of CYP1A2, CYP3A4 and CYP2D6 1

  2. hoursfrom the article text

    What else it turns into

    “On top of being an atypical antipsychotic, Amoxapine, one of the major metabolites of Loxapine, is a tricyclic antidepressant on its own right (though sometimes classified as tetracyclic antidepressant).” 2

  3. half-lifehalf gone

    Elimination half-life

    4 hours (oral); 7.61 hours (inhalation) 1

  4. exitleaves the body

    Excretion

    Majority are excreted within 24 hours, main route through urine (conjugated metabolites), small amounts through the feces (unconjugated metabolites) 1

Sources

  1. Wikipedia, Loxapine, drug infobox (revision 1378838208), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.
  2. Wikipedia, Loxapine, article text (revision 1378838208), CC BY-SA 4.0. Sentences quoted as they appear.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.