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Loratadine

What the body does with Loratadine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

LoratadinetakenDesloratadinemetaboliteExit40% as conjugated metabolites into urine

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    almost 100% 1

  2. hoursbreakdown

    Metabolism

    Liver (CYP2D6- and 3A4-mediated) 1

  3. hoursfrom the article text

    What else it turns into

    “Its metabolite desloratadine, which is largely responsible for the antihistaminergic effects, binds to plasma proteins by 73–76%.” 2

  4. half-lifehalf gone

    Elimination half-life

    8 hours, active metabolite desloratadine 27 hours 1

  5. exitleaves the body

    Excretion

    40% as conjugated metabolites into urine; Similar amount into the feces 1

Sources

  1. Wikipedia, Loratadine, drug infobox (revision 1356896189), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.
  2. Wikipedia, Loratadine, article text (revision 1356896189), CC BY-SA 4.0. Sentences quoted as they appear.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.