intoxicant.wiki2catechol4school
← All metabolic timelinesMetabolic highway

Lofepramine

What the body does with Lofepramine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

LofepraminetakenDesipraminemetaboliteExitUrine, feces (mostly as metabolites)

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    7% 1

  2. hoursbreakdown

    Metabolism

    Hepatic (via cytochrome P450, including CYP2D6) 1

  3. hoursmade from it

    Metabolites

    Desipramine (major) 1

  4. half-lifehalf gone

    Elimination half-life

    Up to 5 hours; 12–24 hours (active metabolites) 1

  5. exitleaves the body

    Excretion

    Urine, feces (mostly as metabolites) 1

Source

  1. Wikipedia, Lofepramine, drug infobox (revision 1328704092), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.