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Lisdexamfetamine

What the body does with Lisdexamfetamine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

LisdexamfetaminetakenDextroamphetaminemetaboliteExitKidney: ~2% as Lisdexamfetamine and ~42%

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    Oral: <2 hours 1

  2. doseabsorbed

    Bioavailability

    Oral: 96.4% 1

  3. hoursbreakdown

    Metabolism

    Hydrolysis by enzymes in red blood cells initially, subsequent metabolism follows 1

  4. hoursmade from it

    Metabolites

    Dextroamphetamine (and its metabolites) and L-lysine 1

  5. half-lifehalf gone

    Elimination half-life

    Lisdexamfetamine: <1 hour; Dextroamphetamine: 10–12 h 1

  6. durationeffects

    Duration of action

    10–14 hours 1

  7. exitleaves the body

    Excretion

    Kidney: ~2% as Lisdexamfetamine and ~42% as Dextroamphetamine 1

Source

  1. Wikipedia, Lisdexamfetamine, drug infobox (revision 1378219195), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.