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Hydrocodone/paracetamol

What the body does with Hydrocodone/paracetamol, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

Hydrocodone/paracetamoltakenExitfor hydrocodone: urinary; for paracetamo

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    >80% 1

  2. hoursbreakdown

    Metabolism

    Hydrocodone: extensively liver, primarily CYP3A4; /Paracetamol: liver, CYP2E1 1

  3. half-lifehalf gone

    Elimination half-life

    for hydrocodone: 228–294 mins (3.8–4.9 hrs); for paracetamol: 120–240 mins (2–4 hrs) 1

  4. exitleaves the body

    Excretion

    for hydrocodone: urinary; for paracetamol: urinary (10–15% unchanged) 1

Source

  1. Wikipedia, Hydrocodone/paracetamol, drug infobox (revision 1373296471), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.