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Hydrocodone/ibuprofen

What the body does with Hydrocodone/ibuprofen, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

Hydrocodone/ibuprofentakenExitfor hydrocodone: urinary; for ibuprofen:

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    >80% 1

  2. hoursbreakdown

    Metabolism

    for hydrocodone: liver, CYP3A4; for ibuprofen: liver, CYP2C9 1

  3. half-lifehalf gone

    Elimination half-life

    for hydrocodone: 228-294 mins (3.8-4.9 hrs); for ibuprofen: 108-120 mins (1.8-2 hrs) 1

  4. exitleaves the body

    Excretion

    for hydrocodone: urinary; for ibuprofen: urine primarily (<1% unchanged) 1

Source

  1. Wikipedia, Hydrocodone/ibuprofen, drug infobox (revision 1368620140), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.