Fruquintinib
What the body does with Fruquintinib, from the dose to the exit, as its Wikipedia drug infobox records it.
Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.
The clock, on a log scale
Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.
- hoursbreakdown
Metabolism
Fruquintinib is primarily eliminated by CYP450 and non-CYP450 (i.e., sulfation and glucuronidation) metabolism. CYP3A and to a lesser extent CYP2C8, CYP2C9, and CYP2C19 are the CYP450 enzymes involved in fruquintinib metabolism. 1
- hoursmade from it
Metabolites
The potency of M11 for inhibiting VEGFR-2 kinase activity is 10 times lower than that of fruquintinib (Takeda data on file); therefore, M11 is not considered an active metabolite. 1
- half-lifehalf gone
Elimination half-life
42hr 1
- exitleaves the body
Excretion
A previous study reported that following administration of 5 mg of radiolabeled fruquintinib, approximately 60% of the dose was recovered in urine (0.50% unchanged) and 30% was recovered in feces (5.34% unchanged), with the remaining radioactivity excreted as metabolites. 1
Source
- Wikipedia, Fruquintinib, drug infobox (revision 1361560227), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.
Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.