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Fosamprenavir

What the body does with Fosamprenavir, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

FosamprenavirtakenAmprenavirmetaboliteExitFecal (as metabolites of amprenavir)

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    Unknown 1

  2. hoursbreakdown

    Metabolism

    Hydrolysed to amprenavir and phosphate in GI tract epithelium 1

  3. hoursfrom the article text

    What else it turns into

    “Amprenavir (the active metabolite of fosamprenavir, which is found in blood plasma, liver and other organs) is metabolized via the liver enzyme CYP3A4 and also weakly inhibits this enzyme.” 2

  4. half-lifehalf gone

    Elimination half-life

    7.7 hours 1

  5. exitleaves the body

    Excretion

    Fecal (as metabolites of amprenavir) 1

Sources

  1. Wikipedia, Fosamprenavir, drug infobox (revision 1368554406), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.
  2. Wikipedia, Fosamprenavir, article text (revision 1368554406), CC BY-SA 4.0. Sentences quoted as they appear.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.