Flupirtine
What the body does with Flupirtine, from the dose to the exit, as its Wikipedia drug infobox records it.
Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.
The clock, on a log scale
Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.
- doseabsorbed
Bioavailability
90% (oral), 70% (rectal) 1
- hoursbreakdown
Metabolism
Hepatic to 2-amino-3-acetylamino-6-(para-fluorobenzylamino) pyridine (which has 20-30% the analgesic potential of its parent compound), para-fluorohippuric acid and a mercapturic acid metabolite, presumably formed from a glutathione adduct 1
- half-lifehalf gone
Elimination half-life
6.5 hours (average), 11.2–16.8 hours (average 14 hours) (elderly), 8.7–10.9 hours (average 9.8 hours) (in those with moderate-level renal impairment) 1
- exitleaves the body
Excretion
72% of flupirtine and its metabolites appear in urine and 18% appear in feces 1
Source
- Wikipedia, Flupirtine, drug infobox (revision 1364201730), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.
Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.