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Estradiol

What the body does with Estradiol, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

EstradioltakenEstronemetaboliteExitUrine: 54%; Feces: 6%

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    Oral: <5%; IM: 100% 1

  2. hoursbreakdown

    Metabolism

    Liver (via hydroxylation, sulfation, glucuronidation) 1

  3. hoursmade from it

    Metabolites

    Major (90%): Estrone; Estrone sulfate; Estrone glucuronide; Estradiol glucuronide 1

  4. half-lifehalf gone

    Elimination half-life

    Oral: 13–20 hours; Sublingual: 8–18 hours; IM (as EV): 4–5 days; IM (as EC): 8–10 days; IV (as E2): 1–2 hours 1

  5. exitleaves the body

    Excretion

    Urine: 54%; Feces: 6% 1

Source

  1. Wikipedia, Estradiol (medication), drug infobox (revision 1377834573), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.