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Efavirenz

What the body does with Efavirenz, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

EfavirenztakenExitKidney (14–34%) and feces (16–61%)

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    3–5 hours 1

  2. doseabsorbed

    Bioavailability

    40–45% (under fasting conditions) 1

  3. hoursbreakdown

    Metabolism

    Liver (CYP2A6 and CYP2B6-mediated) 1

  4. half-lifehalf gone

    Elimination half-life

    Single-dose: 52–76 h; Multi-dose: 40–55 h 1

  5. exitleaves the body

    Excretion

    Kidney (14–34%) and feces (16–61%) 1

Source

  1. Wikipedia, Efavirenz, drug infobox (revision 1373477952), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.