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Donepezil

What the body does with Donepezil, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

DonepeziltakenExit0.11–0.13 (L/h/kg); excreted mostly by t

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    Peak plasma levels in 3–4 h. 1

  2. doseabsorbed

    Bioavailability

    100% 1

  3. hoursbreakdown

    Metabolism

    CYP2D6, CYP3A4, and glucuronidation. Four major metabolites, two of which are active. 1

  4. half-lifehalf gone

    Elimination half-life

    70 hours Around 100 hours in elderly patients. 1

  5. durationeffects

    Duration of action

    With daily dosing, steady-state concentration is reached in 15–21 days. 1

  6. exitleaves the body

    Excretion

    0.11–0.13 (L/h/kg); excreted mostly by the kidneys. Around 17% is excreted unchanged in the urine. About 15% to 20% is excreted in feces. Steady-state clearance is similar at all ages. 1

Source

  1. Wikipedia, Donepezil, drug infobox (revision 1356481650), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.