intoxicant.wiki2catechol4school
← All metabolic timelinesMetabolic highway

Diclofenac

What the body does with Diclofenac, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

DiclofenactakenExit35% bile, 65% urine

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    Within 4 hours (gel), 30 min (non-gel) 1

  2. hoursbreakdown

    Metabolism

    Liver, oxidative, primarily by CYP2C9, also by CYP2C8, CYP3A4, as well as conjugative by glucuronidation (UGT2B7) and sulfation; no active metabolites exist 1

  3. half-lifehalf gone

    Elimination half-life

    1.2–2 h (35% of the drug enters enterohepatic recirculation) 1

  4. exitleaves the body

    Excretion

    35% bile, 65% urine 1

Source

  1. Wikipedia, Diclofenac, drug infobox (revision 1370369641), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.