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Dextromethorphan

What the body does with Dextromethorphan, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

DextromethorphantakenDextrorphanmetaboliteExitKidney

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    11% 1

  2. hoursbreakdown

    Metabolism

    Liver enzymes: major CYP2D6, minor CYP3A4, and minor CYP3A5 1

  3. hoursmade from it

    Metabolites

    Dextrorphan; 3-methoxymorphinan 1

  4. half-lifehalf gone

    Elimination half-life

    2–4 hours (extensive metabolizers); 24 hours (poor metabolizers) 1

  5. durationeffects

    Duration of action

    3–8 hours 1

  6. exitleaves the body

    Excretion

    Kidney 1

Source

  1. Wikipedia, Dextromethorphan, drug infobox (revision 1374989705), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.