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Dacomitinib

What the body does with Dacomitinib, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

DacomitinibtakenExit79% faeces, 3% urine

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    80% 1

  2. hoursbreakdown

    Metabolism

    CYP2D6, CYP3A4 1

  3. hoursmade from it

    Metabolites

    O-desmethyl-dacomitinib 1

  4. half-lifehalf gone

    Elimination half-life

    70 hrs 1

  5. exitleaves the body

    Excretion

    79% faeces, 3% urine 1

Source

  1. Wikipedia, Dacomitinib, drug infobox (revision 1364644463), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.