intoxicant.wiki2catechol4school
← All metabolic timelinesMetabolic highway

Cobimetinib

What the body does with Cobimetinib, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

CobimetinibtakenExitFeces (76–77%), urine (17.9–18%) (after

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    reported from 28% to 46% 1

  2. hoursbreakdown

    Metabolism

    Intestinal and low Liver clearance (mostly CYP3A4 oxidation and UGT2B7 glucuronidation) 1

  3. half-lifehalf gone

    Elimination half-life

    44 hours (mean) 1

  4. exitleaves the body

    Excretion

    Feces (76–77%), urine (17.9–18%) (after oral and IV administration) 1

Source

  1. Wikipedia, Cobimetinib, drug infobox (revision 1329247297), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.