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Clozapine

What the body does with Clozapine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

ClozapinetakenExit80% in metabolized state: 30% biliary an

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    60–70% 1

  2. hoursbreakdown

    Metabolism

    Liver, by several CYP isozymes mainly via CYP2D6 1

  3. half-lifehalf gone

    Elimination half-life

    4–26 hours (mean value 14.2 hours in steady state conditions) 1

  4. exitleaves the body

    Excretion

    80% in metabolized state: 30% biliary and 50% kidney 1

Source

  1. Wikipedia, Clozapine, drug infobox (revision 1374837470), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.