Cladribine
What the body does with Cladribine, from the dose to the exit, as its Wikipedia drug infobox records it.
Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.
The clock, on a log scale
Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.
- doseabsorbed
Bioavailability
100% (i.v.); 37 to 51% (orally) 1
- hoursbreakdown
Metabolism
Mostly via intracellular kinases; 15-18% is excreted unchanged. Intravenous and subcutaneous bolus injection: 15-18% is excreted unchanged After oral administration, 25% (±21%) of dose is excreted unchanged in urine and 3.8% as a metabolite. 1
- half-lifehalf gone
Elimination half-life
Approximately 10 hours after both intravenous infusion and subcutaneous bolus injection ranging from 5.6 to 7.6 hours and 18.4 to 19.7 hours after oral administration, indicative of different elimination phases. 1
- exitleaves the body
Excretion
Urinary 1
Source
- Wikipedia, Cladribine, drug infobox (revision 1378445471), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.
Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.